The role of women in History and Philosophy of Science has largely been neglected. In several European universities the absence of women from the canon of philosophers in regular curricula is remarkable, this absence is even more prominent when the topic of study is related to natural sciences or STEM disciplines. The purpose of this talk is to introduce to the audience the work of two women who worked in natural philosophy: Margaret Cavendish, a singular author from the 17th century and Émilie du Châtelet, an outstanding scholar from the 18th century.